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Select amino acids in DGCR8 are essential for the UGU-pri-miRNA interaction and processing
Microprocessor, composed of DROSHA and DGCR8, processes primary microRNAs (pri-miRNAs) in miRNA biogenesis. Its cleavage efficiency and accuracy are enhanced because DGCR8 interacts with the apical UGU motif of pri-miRNAs. However, the mechanism and influence of DGCR8–UGU interaction on cellular miR...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7334207/ https://ncbi.nlm.nih.gov/pubmed/32620823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1071-5 |
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