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Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a

The Microprocessor complex of DROSHA and DGCR8 initiates the biosynthesis of microRNAs (miRNAs) by processing primary miRNAs (pri-miRNAs). The Microprocessor can be oriented on pri-miRNAs in opposite directions to generate productive and unproductive cleavages at their basal and apical junctions, re...

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Detalhes bibliográficos
Publicado no:RNA
Main Authors: Le, Cong Truc, Nguyen, Thuy Linh, Nguyen, Trung Duc, Nguyen, Tuan Anh
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668254/
https://ncbi.nlm.nih.gov/pubmed/32994184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.077487.120
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