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Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a
The Microprocessor complex of DROSHA and DGCR8 initiates the biosynthesis of microRNAs (miRNAs) by processing primary miRNAs (pri-miRNAs). The Microprocessor can be oriented on pri-miRNAs in opposite directions to generate productive and unproductive cleavages at their basal and apical junctions, re...
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| Publicat a: | RNA |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7668254/ https://ncbi.nlm.nih.gov/pubmed/32994184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.077487.120 |
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