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The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor

The human Microprocessor complex cleaves primary microRNA (miRNA) transcripts (pri-miRNAs) to initiate miRNA synthesis. Microprocessor consists of DROSHA (an RNase III enzyme), and DGCR8. DROSHA contains two RNase III domains, RIIIDa and RIIIDb, which simultaneously cleave the 3p- and 5p-strands of...

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Foilsithe in:Nucleic Acids Res
Main Authors: Nguyen, Thuy Linh, Nguyen, Trung Duc, Bao, Sheng, Li, Shaohua, Nguyen, Tuan Anh
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049713/
https://ncbi.nlm.nih.gov/pubmed/31956890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa018
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