The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor

The human Microprocessor complex cleaves primary microRNA (miRNA) transcripts (pri-miRNAs) to initiate miRNA synthesis. Microprocessor consists of DROSHA (an RNase III enzyme), and DGCR8. DROSHA contains two RNase III domains, RIIIDa and RIIIDb, which simultaneously cleave the 3p- and 5p-strands of...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Nguyen, Thuy Linh, Nguyen, Trung Duc, Bao, Sheng, Li, Shaohua, Nguyen, Tuan Anh
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049713/
https://ncbi.nlm.nih.gov/pubmed/31956890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa018
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items