The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor

The human Microprocessor complex cleaves primary microRNA (miRNA) transcripts (pri-miRNAs) to initiate miRNA synthesis. Microprocessor consists of DROSHA (an RNase III enzyme), and DGCR8. DROSHA contains two RNase III domains, RIIIDa and RIIIDb, which simultaneously cleave the 3p- and 5p-strands of...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Nguyen, Thuy Linh, Nguyen, Trung Duc, Bao, Sheng, Li, Shaohua, Nguyen, Tuan Anh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Nucleic Acid Enzymes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049713/
https://ncbi.nlm.nih.gov/pubmed/31956890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa018
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