Select amino acids in DGCR8 are essential for the UGU-pri-miRNA interaction and processing

Microprocessor, composed of DROSHA and DGCR8, processes primary microRNAs (pri-miRNAs) in miRNA biogenesis. Its cleavage efficiency and accuracy are enhanced because DGCR8 interacts with the apical UGU motif of pri-miRNAs. However, the mechanism and influence of DGCR8–UGU interaction on cellular miR...

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Vydáno v:Commun Biol
Hlavní autoři: Dang, Thi Lieu, Le, Cong Truc, Le, Minh Ngoc, Nguyen, Trung Duc, Nguyen, Thuy Linh, Bao, Sheng, Li, Shaohua, Nguyen, Tuan Anh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334207/
https://ncbi.nlm.nih.gov/pubmed/32620823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-1071-5
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