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Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundamental cellular processes. PIKK family member SMG1 orchestrates progression of an RNA quality control pathway, termed nonsense-mediated mRNA decay (NMD), by phosphorylating the NM...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7334022/ https://ncbi.nlm.nih.gov/pubmed/32469312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57127 |
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