A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation

Mammalian nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that degrades mRNAs containing premature translation termination codons. Phosphorylation of the essential NMD effector UPF1 by the phosphoinositide-3-kinase-like kinase (PIKK) SMG-1 is a key step in NMD and occurs wh...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nucleic Acids Res
मुख्य लेखकों: Deniaud, Aurélien, Karuppasamy, Manikandan, Bock, Thomas, Masiulis, Simonas, Huard, Karine, Garzoni, Frédéric, Kerschgens, Kathrin, Hentze, Matthias W., Kulozik, Andreas E., Beck, Martin, Neu-Yilik, Gabriele, Schaffitzel, Christiane
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2015
विषय:
Structural Biology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551919/
https://ncbi.nlm.nih.gov/pubmed/26130714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv668
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन