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Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
Wnt signalling is dependent on dishevelled proteins (DVL1-3), which assemble an intracellular Wnt signalosome at the plasma membrane. The levels of DVL1-3 are regulated by multiple Cullin-RING E3 ligases that mediate their ubiquitination and degradation. The BTB-Kelch protein KLHL12 was the first E3...
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| Publicado en: | Open Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Royal Society
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7333892/ https://ncbi.nlm.nih.gov/pubmed/32574548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.200041 |
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