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Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells
The adrenal gland has traditionally been viewed as a source of “weak androgens”; however, emerging evidence indicates 11-oxy-androgens of adrenal origin are metabolized in peripheral tissues to potent androgens. Also emerging is the role of gut bacteria in the conversion of C(21) glucocorticoids to...
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| Publicat a: | J Steroid Biochem Mol Biol |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7333170/ https://ncbi.nlm.nih.gov/pubmed/31870912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2019.105567 |
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