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Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells

The adrenal gland has traditionally been viewed as a source of “weak androgens”; however, emerging evidence indicates 11-oxy-androgens of adrenal origin are metabolized in peripheral tissues to potent androgens. Also emerging is the role of gut bacteria in the conversion of C(21) glucocorticoids to...

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Detalhes bibliográficos
Publicado no:J Steroid Biochem Mol Biol
Main Authors: Ly, Lindsey K., Rowles, Joe L., Paul, Hans Müller, Alves, João M.P., Yemm, Camdon, Wolf, Patricia M., Devendran, Saravanan, Hudson, Matthew E., Morris, David J., Erdman, John W., Ridlon, Jason M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7333170/
https://ncbi.nlm.nih.gov/pubmed/31870912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2019.105567
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