Inhibition of mTOR via an AAV-Delivered shRNA Tested in a Rat OIR Model as a Potential Antiangiogenic Gene Therapy

PURPOSE: Recent studies have shown that inhibitors of the mechanistic target of rapamycin (mTOR) play important roles in proliferating endothelial cells within the retinal vasculature. Here we explore the effects of inhibiting mTOR as a potential gene therapeutic against pathological retinal angioge...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Lee, Steven Hyun Seung, Chang, HeeSoon, Kim, Ji Hyun, Kim, Hee Jong, Choi, Jun-Sub, Chung, Sunho, Woo, Ha-Na, Lee, Kyoung Jin, Park, Keerang, Lee, Joo Yong, Lee, Heuiran
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329967/
https://ncbi.nlm.nih.gov/pubmed/32106292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.2.45
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