Inhibition of mTOR via an AAV-Delivered shRNA Tested in a Rat OIR Model as a Potential Antiangiogenic Gene Therapy

PURPOSE: Recent studies have shown that inhibitors of the mechanistic target of rapamycin (mTOR) play important roles in proliferating endothelial cells within the retinal vasculature. Here we explore the effects of inhibiting mTOR as a potential gene therapeutic against pathological retinal angioge...

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Dettagli Bibliografici
Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Lee, Steven Hyun Seung, Chang, HeeSoon, Kim, Ji Hyun, Kim, Hee Jong, Choi, Jun-Sub, Chung, Sunho, Woo, Ha-Na, Lee, Kyoung Jin, Park, Keerang, Lee, Joo Yong, Lee, Heuiran
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2020
Soggetti:
Retina
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329967/
https://ncbi.nlm.nih.gov/pubmed/32106292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.2.45
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