Apolipoprotein B Knockdown by AAV-delivered shRNA Lowers Plasma Cholesterol in Mice

Serum low-density lipoprotein cholesterol (LDL-C) levels are proportionate to the risk of atherosclerotic cardiovascular disease. In order to reduce serum total cholesterol and LDL-C levels in mice, RNA interference (RNAi) was used to inhibit expression of the structural protein of LDL-C, apolipopro...

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Dettagli Bibliografici
Autori principali: Koornneef, Annemart, Maczuga, Piotr, van Logtenstein, Richard, Borel, Florie, Blits, Bas, Ritsema, Tita, van Deventer, Sander, Petry, Harald, Konstantinova, Pavlina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070114/
https://ncbi.nlm.nih.gov/pubmed/21304496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.6
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