Embedding siRNA sequences targeting Apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy

Overexpression of short hairpin RNA (shRNA) often causes cytotoxicity and using microRNA (miRNA) scaffolds can circumvent this problem. In this study, identically predicted small interfering RNA (siRNA) sequences targeting apolipoprotein B100 (siApoB) were embedded in shRNA (shApoB) or miRNA (miApoB...

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Detalhes bibliográficos
Main Authors: Maczuga, Piotr, Lubelski, Jacek, van Logtenstein, Richard, Borel, Florie, Blits, Bas, Fakkert, Erwin, Costessi, Adalberto, Butler, Derek, van Deventer, Sander, Petry, Harald, Koornneef, Annemart, Konstantinova, Pavlina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538299/
https://ncbi.nlm.nih.gov/pubmed/23089734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.160
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