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Engineered receptors for human cytomegalovirus that are orthogonal to normal human biology
A trimeric glycoprotein complex on the surface of human cytomegalovirus (HCMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate host cell recognition and fusion of the viral and cellular membranes. Soluble PDGFRα potently neutralizes HCMV in tissue culture, and its poten...
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| Pubblicato in: | PLoS Pathog |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7329128/ https://ncbi.nlm.nih.gov/pubmed/32559251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008647 |
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