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Inhibition of HSP90 and activation of HSF1 diminishes macrophage NLRP3 inflammasome activity in alcoholic liver injury
BACKGROUND: Activation of NLRP3 in liver macrophages contributes to alcoholic liver disease (ALD). Molecular chaperone heat shock protein (HSP) 90 facilitates NLRP3 inflammasome activity during infections and inflammatory diseases. We previously reported that HSP90 is induced in ALD and regulates pr...
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| Udgivet i: | Alcohol Clin Exp Res |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7328660/ https://ncbi.nlm.nih.gov/pubmed/32282939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.14338 |
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