Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome

Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing Hsp90. In response to stress stimuli, Hsp90 is released, and NLRP3 can be activa...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Piippo, Niina, Korhonen, Eveliina, Hytti, Maria, Skottman, Heli, Kinnunen, Kati, Josifovska, Natasha, Petrovski, Goran, Kaarniranta, Kai, Kauppinen, Anu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928092/
https://ncbi.nlm.nih.gov/pubmed/29712950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25123-2
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