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Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing Hsp90. In response to stress stimuli, Hsp90 is released, and NLRP3 can be activa...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5928092/ https://ncbi.nlm.nih.gov/pubmed/29712950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25123-2 |
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