Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. During thymus organogenesis, these functionally...

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Detaylı Bibliyografya
Yayımlandı:Development
Asıl Yazarlar: Liu, Dong, Kousa, Anastasia I., O'Neill, Kathy E., Rouse, Paul, Popis, Martyna, Farley, Alison M., Tomlinson, Simon R., Ulyanchenko, Svetlana, Guillemot, Francois, Seymour, Philip A., Jørgensen, Mette C., Serup, Palle, Koch, Ute, Radtke, Freddy, Blackburn, C. Clare
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2020
Konular:
Stem Cells and Regeneration
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328009/
https://ncbi.nlm.nih.gov/pubmed/32467237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.178582
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