Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. During thymus organogenesis, these functionally...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Development
Päätekijät: Liu, Dong, Kousa, Anastasia I., O'Neill, Kathy E., Rouse, Paul, Popis, Martyna, Farley, Alison M., Tomlinson, Simon R., Ulyanchenko, Svetlana, Guillemot, Francois, Seymour, Philip A., Jørgensen, Mette C., Serup, Palle, Koch, Ute, Radtke, Freddy, Blackburn, C. Clare
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Company of Biologists Ltd 2020
Aiheet:
Stem Cells and Regeneration
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328009/
https://ncbi.nlm.nih.gov/pubmed/32467237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.178582
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