Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. During thymus organogenesis, these functionally...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Development
Egile Nagusiak: Liu, Dong, Kousa, Anastasia I., O'Neill, Kathy E., Rouse, Paul, Popis, Martyna, Farley, Alison M., Tomlinson, Simon R., Ulyanchenko, Svetlana, Guillemot, Francois, Seymour, Philip A., Jørgensen, Mette C., Serup, Palle, Koch, Ute, Radtke, Freddy, Blackburn, C. Clare
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2020
Gaiak:
Stem Cells and Regeneration
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328009/
https://ncbi.nlm.nih.gov/pubmed/32467237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.178582
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