Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. During thymus organogenesis, these functionally...

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Pubblicato in:Development
Autori principali: Liu, Dong, Kousa, Anastasia I., O'Neill, Kathy E., Rouse, Paul, Popis, Martyna, Farley, Alison M., Tomlinson, Simon R., Ulyanchenko, Svetlana, Guillemot, Francois, Seymour, Philip A., Jørgensen, Mette C., Serup, Palle, Koch, Ute, Radtke, Freddy, Blackburn, C. Clare
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2020
Soggetti:
Stem Cells and Regeneration
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328009/
https://ncbi.nlm.nih.gov/pubmed/32467237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.178582
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