Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

Thymus function depends on the epithelial compartment of the thymic stroma. Cortical thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) TECs impose central tolerance on the T cell repertoire. During thymus organogenesis, these functionally...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Development
Prif Awduron: Liu, Dong, Kousa, Anastasia I., O'Neill, Kathy E., Rouse, Paul, Popis, Martyna, Farley, Alison M., Tomlinson, Simon R., Ulyanchenko, Svetlana, Guillemot, Francois, Seymour, Philip A., Jørgensen, Mette C., Serup, Palle, Koch, Ute, Radtke, Freddy, Blackburn, C. Clare
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2020
Pynciau:
Stem Cells and Regeneration
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328009/
https://ncbi.nlm.nih.gov/pubmed/32467237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.178582
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