Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

Many oncogenes enhance nucleotide usage to increase ribosome content, DNA replication, and cell proliferation, but in parallel trigger p53 activation. Both the impaired ribosome biogenesis checkpoint (IRBC) and the DNA damage response (DDR) have been implicated in p53 activation following nucleotide...

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Bibliografiska uppgifter
I publikationen:EMBO J
Huvudupphovsmän: Pelletier, Joffrey, Riaño‐Canalias, Ferran, Almacellas, Eugènia, Mauvezin, Caroline, Samino, Sara, Feu, Sonia, Menoyo, Sandra, Domostegui, Ana, Garcia‐Cajide, Marta, Salazar, Ramon, Cortés, Constanza, Marcos, Ricard, Tauler, Albert, Yanes, Oscar, Agell, Neus, Kozma, Sara C, Gentilella, Antonio, Thomas, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327477/
https://ncbi.nlm.nih.gov/pubmed/32484960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103838
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