Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

Many oncogenes enhance nucleotide usage to increase ribosome content, DNA replication, and cell proliferation, but in parallel trigger p53 activation. Both the impaired ribosome biogenesis checkpoint (IRBC) and the DNA damage response (DDR) have been implicated in p53 activation following nucleotide...

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Vydáno v:EMBO J
Hlavní autoři: Pelletier, Joffrey, Riaño‐Canalias, Ferran, Almacellas, Eugènia, Mauvezin, Caroline, Samino, Sara, Feu, Sonia, Menoyo, Sandra, Domostegui, Ana, Garcia‐Cajide, Marta, Salazar, Ramon, Cortés, Constanza, Marcos, Ricard, Tauler, Albert, Yanes, Oscar, Agell, Neus, Kozma, Sara C, Gentilella, Antonio, Thomas, George
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327477/
https://ncbi.nlm.nih.gov/pubmed/32484960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103838
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