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Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage
Many oncogenes enhance nucleotide usage to increase ribosome content, DNA replication, and cell proliferation, but in parallel trigger p53 activation. Both the impaired ribosome biogenesis checkpoint (IRBC) and the DNA damage response (DDR) have been implicated in p53 activation following nucleotide...
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| Publicado en: | EMBO J |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7327477/ https://ncbi.nlm.nih.gov/pubmed/32484960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103838 |
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