Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1

Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1 activation. Here, we demonstrate that glucose potentiates E2F1-ind...

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Detaylı Bibliyografya
Yayımlandı:iScience
Asıl Yazarlar: Almacellas, Eugènia, Pelletier, Joffrey, Manzano, Anna, Gentilella, Antonio, Ambrosio, Santiago, Mauvezin, Caroline, Tauler, Albert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818336/
https://ncbi.nlm.nih.gov/pubmed/31627130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.040
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