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Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1
Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1 activation. Here, we demonstrate that glucose potentiates E2F1-ind...
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| Publié dans: | iScience |
|---|---|
| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6818336/ https://ncbi.nlm.nih.gov/pubmed/31627130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.040 |
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