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E2F1 Regulates Cellular Growth by mTORC1 Signaling

During cell proliferation, growth must occur to maintain homeostatic cell size. Here we show that E2F1 is capable of inducing growth by regulating mTORC1 activity. The activation of cell growth and mTORC1 by E2F1 is dependent on both E2F1's ability to bind DNA and to regulate gene transcription...

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Detalhes bibliográficos
Main Authors: Real, Sebastian, Meo-Evoli, Nathalie, Espada, Lilia, Tauler, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026008/
https://ncbi.nlm.nih.gov/pubmed/21283628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016163
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