Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

MYC-driven B-cell lymphomas are addicted to increased levels of ribosome biogenesis (RiBi), offering the potential for therapeutic intervention. However, it is unclear whether inhibition of RiBi suppresses lymphomagenesis by decreasing translational capacity and/or by p53 activation mediated by the...

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Veröffentlicht in:Blood
Hauptverfasser: Domostegui, Ana, Peddigari, Suresh, Mercer, Carol A., Iannizzotto, Flavia, Rodriguez, Marta L., Garcia-Cajide, Marta, Amador, Virginia, Diepstraten, Sarah T., Kelly, Gemma L., Salazar, Ramón, Kozma, Sara C., Kusnadi, Eric P., Kang, Jian, Gentilella, Antonio, Pearson, Richard B., Thomas, George, Pelletier, Joffrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212515/
https://ncbi.nlm.nih.gov/pubmed/33512431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007452
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