Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

MYC-driven B-cell lymphomas are addicted to increased levels of ribosome biogenesis (RiBi), offering the potential for therapeutic intervention. However, it is unclear whether inhibition of RiBi suppresses lymphomagenesis by decreasing translational capacity and/or by p53 activation mediated by the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Domostegui, Ana, Peddigari, Suresh, Mercer, Carol A., Iannizzotto, Flavia, Rodriguez, Marta L., Garcia-Cajide, Marta, Amador, Virginia, Diepstraten, Sarah T., Kelly, Gemma L., Salazar, Ramón, Kozma, Sara C., Kusnadi, Eric P., Kang, Jian, Gentilella, Antonio, Pearson, Richard B., Thomas, George, Pelletier, Joffrey
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2021
Gaiak:
Lymphoid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8212515/
https://ncbi.nlm.nih.gov/pubmed/33512431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007452
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