AUTOGENOUS CONTROL OF 5′TOP mRNA STABILITY BY 40S RIBOSOMES

Ribosomal protein (RP) expression in higher eukaryotes is regulated translationally, through the 5′TOP sequence. This mechanism evolved to more rapidly produce RPs on demand in different tissues. Here we show that 40S ribosomes, in a complex with mRNA binding protein LARP1, selectively stabilize 5′T...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Gentilella, Antonio, Morón-Duran, Francisco D., Fuentes, Pedro, Zweig-Rocha, Guilherme, Riaño-Canalias, Ferran, Pelletier, Joffrey, Ruiz, Marta, Turón, Gemma, Castaño, Julio, Tauler, Albert, Bueno, Clara, Menéndez, Pablo, Kozma, Sara C., Thomas, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553558/
https://ncbi.nlm.nih.gov/pubmed/28673543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.005
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