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Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deleti...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tamming, Renee J., Dumeaux, Vanessa, Jiang, Yan, Shafiq, Sarfraz, Langlois, Luana, Ellegood, Jacob, Qiu, Lily R., Lerch, Jason P., Bérubé, Nathalie G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Authors. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326465/
https://ncbi.nlm.nih.gov/pubmed/32610139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107838
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