Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deleti...

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Publicat a:Cell Rep
Autors principals: Tamming, Renee J., Dumeaux, Vanessa, Jiang, Yan, Shafiq, Sarfraz, Langlois, Luana, Ellegood, Jacob, Qiu, Lily R., Lerch, Jason P., Bérubé, Nathalie G.
Format: Artigo
Idioma:Inglês
Publicat: The Authors. 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326465/
https://ncbi.nlm.nih.gov/pubmed/32610139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107838
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