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Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior.

The importance of chromatin-mediated processes in neurodevelopmental and intellectual disability disorders is well recognized. However, how chromatin dysregulation in glial cells impacts cognitive abilities is less well understood. Here, we demonstrate that targeted loss of the ATRX chromatin remode...

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Xehetasun bibliografikoak
Egile Nagusiak: Sarfraz Shafiq, Alireza Ghahramani, Kasha Mansour, Miguel Pena-Ortiz, Julia K Sunstrum, Milica Pavlovic, Yan Jiang, Megan E Rowland, Wataru Inoue, Nathalie G Bérubé
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science (PLoS) 2025-09-01
Saila:PLoS Biology
Sarrera elektronikoa:https://doi.org/10.1371/journal.pbio.3002659
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