Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

ATRX gene mutations have been identified in syndromic and non-syndromic intellectual disabilities in humans. ATRX is known to maintain genomic stability in neuroprogenitor cells, but its function in differentiated neurons and memory processes remains largely unresolved. Here, we show that the deleti...

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Udgivet i:Cell Rep
Main Authors: Tamming, Renee J., Dumeaux, Vanessa, Jiang, Yan, Shafiq, Sarfraz, Langlois, Luana, Ellegood, Jacob, Qiu, Lily R., Lerch, Jason P., Bérubé, Nathalie G.
Format: Artigo
Sprog:Inglês
Udgivet: The Authors. 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326465/
https://ncbi.nlm.nih.gov/pubmed/32610139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107838
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