Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically‐Based Pharmacokinetic Modeling

Antiretroviral therapy during pregnancy reduces the risk of vertical HIV‐1 transmission. However, drug dosing is challenging as pharmacokinetics (PK) may be altered during pregnancy. We combined a pregnancy physiologically‐based pharmacokinetic (PBPK) modeling approach with data on placental drug tr...

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Bibliografische gegevens
Gepubliceerd in:Clin Pharmacol Ther
Hoofdauteurs: Freriksen, Jolien J.M., Schalkwijk, Stein, Colbers, Angela P., Abduljalil, Khaled, Russel, Frans G.M., Burger, David M., Greupink, Rick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325314/
https://ncbi.nlm.nih.gov/pubmed/31868223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1748
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