Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically‐Based Pharmacokinetic Modeling

Antiretroviral therapy during pregnancy reduces the risk of vertical HIV‐1 transmission. However, drug dosing is challenging as pharmacokinetics (PK) may be altered during pregnancy. We combined a pregnancy physiologically‐based pharmacokinetic (PBPK) modeling approach with data on placental drug tr...

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Bibliografski detalji
Izdano u:Clin Pharmacol Ther
Glavni autori: Freriksen, Jolien J.M., Schalkwijk, Stein, Colbers, Angela P., Abduljalil, Khaled, Russel, Frans G.M., Burger, David M., Greupink, Rick
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325314/
https://ncbi.nlm.nih.gov/pubmed/31868223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1748
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