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Placental transfer and tissue accumulation of dolutegravir in the ex vivo human cotyledon perfusion model
OBJECTIVE: To determine the transplacental pharmacokinetics of the HIV integrase inhibitor dolutegravir. STUDY DESIGN: Maternal-to-fetal transfer across the term human placenta was investigated with the ex-vivo dually perfused cotyledon model, in 5 closed-circuit, recirculating experiments. Dolutegr...
Enregistré dans:
| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692001/ https://ncbi.nlm.nih.gov/pubmed/31408460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220323 |
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