Placental Transfer of Maraviroc in an Ex Vivo Human Cotyledon Perfusion Model and Influence of ABC Transporter Expression

Nowadays, antiretroviral therapy is recommended during pregnancy to prevent mother-to-child transmission of HIV. However, for many antiretroviral drugs, including maraviroc, a CCR5 antagonist, very little data exist regarding placental transfer. Besides, various factors may modulate this transfer, i...

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Bibliographic Details
Main Authors: Vinot, C., Gavard, L., Tréluyer, J. M., Manceau, S., Courbon, E., Scherrmann, J. M., Declèves, X., Duro, D., Peytavin, G., Mandelbrot, L., Giraud, C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591923/
https://ncbi.nlm.nih.gov/pubmed/23295922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01821-12
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