Placental transfer and tissue accumulation of dolutegravir in the ex vivo human cotyledon perfusion model

OBJECTIVE: To determine the transplacental pharmacokinetics of the HIV integrase inhibitor dolutegravir. STUDY DESIGN: Maternal-to-fetal transfer across the term human placenta was investigated with the ex-vivo dually perfused cotyledon model, in 5 closed-circuit, recirculating experiments. Dolutegr...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mandelbrot, Laurent, Ceccaldi, Pierre-François, Duro, Dominique, Lê, Minh, Pencolé, Lucile, Peytavin, Gilles
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692001/
https://ncbi.nlm.nih.gov/pubmed/31408460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220323
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