Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling

BACKGROUND: Fetal antiretroviral exposure is usually derived from the cord-to-maternal concentration ratio. This static parameter does not provide information on the pharmacokinetics in utero, limiting the assessment of a fetal exposure–effect relationship. OBJECTIVE: The aim of this study was to in...

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Bibliographic Details
Published in:Clin Pharmacokinet
Main Authors: Schalkwijk, Stein, Buaben, Aaron O., Freriksen, Jolien J. M., Colbers, Angela P., Burger, David M., Greupink, Rick, Russel, Frans G. M.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2017
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Original Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974000/
https://ncbi.nlm.nih.gov/pubmed/28744795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0583-8
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