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Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling
BACKGROUND: Fetal antiretroviral exposure is usually derived from the cord-to-maternal concentration ratio. This static parameter does not provide information on the pharmacokinetics in utero, limiting the assessment of a fetal exposure–effect relationship. OBJECTIVE: The aim of this study was to in...
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| Publicado no: | Clin Pharmacokinet |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5974000/ https://ncbi.nlm.nih.gov/pubmed/28744795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0583-8 |
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