Development of a Conformational Histamine H(3) Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists

[Image: see text] The histamine H(3) receptor (H(3)R) represents a highly attractive drug target for the treatment of various central nervous system disorders, but the discovery of novel H(3)R targeting compounds relies on the assessment of highly amplified intracellular signaling events that do not...

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Detalhes bibliográficos
Publicado no:ACS Sens
Main Authors: Schihada, Hannes, Ma, Xiaoyuan, Zabel, Ulrike, Vischer, Henry F., Schulte, Gunnar, Leurs, Rob, Pockes, Steffen, Lohse, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325232/
https://ncbi.nlm.nih.gov/pubmed/32397705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssensors.0c00397
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