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In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor

Abstract The Apelin receptor (APLNR), a class A G-protein coupled receptor, plays a crucial role during cardiovascular development and tumor angiogenesis. To understand its spatiotemporal activity in health and disease is fundamental for the development of drugs to manipulate its activation state. T...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Lukas Herdt, Hannes Schihada, Michael Kurz, Sebastian Ernst, Jean Eberlein, Peter Kolb, Cornelius Krasel, Moritz Bünemann, Christian S. M. Helker
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2025-07-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-025-61781-3
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