Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

BACKGROUND: Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the resting enzyme resemble the conformations of intermediate states in the catalytic process. Previous work on the subtilisin protease,...

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Vydáno v:PeerJ
Hlavní autoři: Wu, Shanshan, Nguyen, Tam T.T.N., Moroz, Olga V., Turkenburg, Johan P., Nielsen, Jens E., Wilson, Keith S., Rand, Kasper D., Teilum, Kaare
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2020
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323712/
https://ncbi.nlm.nih.gov/pubmed/32617193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9408
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