Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

BACKGROUND: Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the resting enzyme resemble the conformations of intermediate states in the catalytic process. Previous work on the subtilisin protease,...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Wu, Shanshan, Nguyen, Tam T.T.N., Moroz, Olga V., Turkenburg, Johan P., Nielsen, Jens E., Wilson, Keith S., Rand, Kasper D., Teilum, Kaare
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2020
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323712/
https://ncbi.nlm.nih.gov/pubmed/32617193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9408
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