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HDX-MS Guided Drug Discovery: Small Molecules and Biopharmaceuticals

Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS or DXMS) has emerged as an important tool for the development of small molecule therapeutics and biopharmaceuticals. Central to these advances have been improvements to automated HDX-MS platforms and software that allow for the rapid...

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Detalhes bibliográficos
Publicado no:Curr Opin Struct Biol
Main Authors: Marciano, David P., Dharmarajan, Venkatasubramanian, Griffin, Patrick R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253076/
https://ncbi.nlm.nih.gov/pubmed/25179005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2014.08.007
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