Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Morissette, Pierre, Polak, Sebastian, Chain, Anne, Zhai, Jin, Imredy, John P., Wildey, Mary Jo, Travis, Jeffrey, Fitzgerald, Kevin, Fanelli, Patrick, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick, Regan, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322544/
https://ncbi.nlm.nih.gov/pubmed/31981640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.114883
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