Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in...

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Bibliographic Details
Published in:Toxicol Appl Pharmacol
Main Authors: Morissette, Pierre, Polak, Sebastian, Chain, Anne, Zhai, Jin, Imredy, John P., Wildey, Mary Jo, Travis, Jeffrey, Fitzgerald, Kevin, Fanelli, Patrick, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick, Regan, Christopher
Format: Artigo
Language:Inglês
Published: Academic Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322544/
https://ncbi.nlm.nih.gov/pubmed/31981640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.114883
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