Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in...

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Pubblicato in:Toxicol Appl Pharmacol
Autori principali: Morissette, Pierre, Polak, Sebastian, Chain, Anne, Zhai, Jin, Imredy, John P., Wildey, Mary Jo, Travis, Jeffrey, Fitzgerald, Kevin, Fanelli, Patrick, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick, Regan, Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: Academic Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322544/
https://ncbi.nlm.nih.gov/pubmed/31981640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.114883
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