Loading...
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay
Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in...
Saved in:
| Published in: | Toxicol Appl Pharmacol |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Academic Press
2020
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7322544/ https://ncbi.nlm.nih.gov/pubmed/31981640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2020.114883 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|