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Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias

BACKGROUND AND PURPOSE: Early identification of drug‐induced cardiac adverse events is key in drug development. Human‐based computer models are emerging as an effective approach, complementary to in vitro and animal models. Drug‐induced shortening of the electromechanical window has been associated...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Passini, Elisa, Trovato, Cristian, Morissette, Pierre, Sannajust, Frederick, Bueno‐Orovio, Alfonso, Rodriguez, Blanca
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780030/
https://ncbi.nlm.nih.gov/pubmed/31271649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14786
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