Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias

BACKGROUND AND PURPOSE: Early identification of drug‐induced cardiac adverse events is key in drug development. Human‐based computer models are emerging as an effective approach, complementary to in vitro and animal models. Drug‐induced shortening of the electromechanical window has been associated...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Passini, Elisa, Trovato, Cristian, Morissette, Pierre, Sannajust, Frederick, Bueno‐Orovio, Alfonso, Rodriguez, Blanca
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780030/
https://ncbi.nlm.nih.gov/pubmed/31271649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14786
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