Inter-study variability of preclinical in vivo safety studies and translational exposure–QTc relationships – a PKPD meta-analysis

BACKGROUND AND PURPOSE: Preclinical cardiovascular safety studies (CVS) have been compared between facilities with respect to their sensitivity to detect drug-induced QTc prolongation (ΔQTc). Little is known about the consistency of quantitative ΔQTc predictions that are relevant for translation to...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Gotta, V, Cools, F, van Ammel, K, Gallacher, D J, Visser, S A G, Sannajust, F, Morissette, P, Danhof, M, van der Graaf, P H
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556474/
https://ncbi.nlm.nih.gov/pubmed/26076100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13218
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