Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1

Indoximod has shaped our understanding of the biology of IDO1 in the control of immune responses, though its mechanism of action has been poorly understood. Previous studies demonstrated that indoximod creates a tryptophan (Trp) sufficiency signal that reactivates mTOR in the context of low Trp conc...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Brincks, Erik L., Adams, James, Wang, Lifu, Turner, Benjamin, Marcinowicz, Agnieszka, Ke, Jiyuan, Essmann, Michael, Mautino, Lucía M., Allen, Clarissa Van, Kumar, Sanjeev, Vahanian, Nicholas, Link, Charles, Mautino, Mario R.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321702/
https://ncbi.nlm.nih.gov/pubmed/32637034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27646
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