Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1

Indoximod has shaped our understanding of the biology of IDO1 in the control of immune responses, though its mechanism of action has been poorly understood. Previous studies demonstrated that indoximod creates a tryptophan (Trp) sufficiency signal that reactivates mTOR in the context of low Trp conc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Brincks, Erik L., Adams, James, Wang, Lifu, Turner, Benjamin, Marcinowicz, Agnieszka, Ke, Jiyuan, Essmann, Michael, Mautino, Lucía M., Allen, Clarissa Van, Kumar, Sanjeev, Vahanian, Nicholas, Link, Charles, Mautino, Mario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321702/
https://ncbi.nlm.nih.gov/pubmed/32637034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27646
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