Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway

Indoleamine 2,3-dioxygenase 1 (IDO1), indoleamine 2,3-dioxygenase 2 (IDO2), and tryptophan 2,3-dioxygenase (TDO) initiate the first step of the kynurenine pathway (KP), leading to the transformation of l-tryptophan (Trp) into l-kynurenine (Kyn) and other downstream metabolites. Kyn is known as an en...

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Bibliografiska uppgifter
I publikationen:Signal Transduct Target Ther
Huvudupphovsmän: Du, Lisha, Xing, Zikang, Tao, Bangbao, Li, Tianqi, Yang, Dan, Li, Weirui, Zheng, Yuanting, Kuang, Chunxiang, Yang, Qing
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033114/
https://ncbi.nlm.nih.gov/pubmed/32296044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0103-4
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